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Objective To analyze the plasty of the tip framework and the nasal tip in insufficient-lining cases with auricular and septal cartilage.Methods The tip framework was formed by using septal extension graft (SEG) and columellar strut (CS) to construct the main framework of nasal tip,and then according to the size of the graft the next processes were chosen for supporting structure.When the graft size met the tip position,the caudal margin of the framework could be beyond the maximum stretch position of the lower lateral cartilage and reached or was close to the expected tip position.When the graft size was insufficient,auricular cartilage was used to hold the caudal margin of the framework to extend or to heighten the framework further.Refined plasty of nasal tip was as follows:when the end of framework was higher than or equal to the dome above 3 mm,auricular cartilage strip was used to reconstruct the dome;when less than 3 mm,multilayer onlay grafts were used to heighten the dome.Results From May 2013 to May 2015,42 cases were followed up from 6 months to 18 months.18 cases belonged to the type 1,including 13 cases using ear cartilage to reconstruct dome,5 cases using onlay graft;24 cases belonged to the type 2,including 14 cases using onlay graft and 10 cases using ear cartilage to reconstruct the dome.They all got good results.Conclusions To the insufficient lining cases,the appropriate method can be chosen to form stable tip framework according to the preoperative design and the graft size.Then onlay grafts or dome reconstruction technique is used to form the tip.Most of the insufficient-lining cases can get satisfactory results.
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Household questionnaire survey was conducted in 200 residents of Tilan and Zhanhqiao neighborhoods, Xingang community, Shanghai to know their awareness of knowledge about pulmonary tuberculosis (TB) prevention and treatment. Results showed that 87.0% of the residents surveyed knew TB symptoms, but only 42. 5% knew cough and expectoration were pulmonary TB symptoms, 76. 5 % knew that TB could not be transmitted by use something that was used by TB patients, 85.5 % knew government policy of free and payment reduction for TB treatment, and 82. 0% knew there existed some hospitals for TB treatment designated by local health administrations. There was significant difference in the awareness between the two neighborhoods ( P ＜ 0. 01 ). Factors related to their awareness of TB prevention and treatment knowledge included family annual income, educational level, publicity by telecision and broadcasting.
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OBJECTIVE To study the antibacterial activity of pazufloxacin in vitro against bacteria isolated from(patients) with respiratory and urinary tract infection,compared with levofloxacin,ciprofloxacin,cefuroxime and(cefotaxime) to provide guideline for clinical application.METHODS The infected bacteria were identified by the(fully) automatic VITEK system.The susceptibility test was determined by MIC method and K-B disk diffusion method respectively.RESULTS The sensitivity of most Gram-negative bacteria to pazufloxacin was basically the same to levofloxacin,cefotaxime, etc.However,the sensitivity of Pseudomonas and Acinetobacter to(pazufloxacin) was higher than to other four antibiotics;the sensitivity of Gram-positive cocci,particularly(Streptococcus) to(pazufloxacin) was obviously lower than cephalosporins and no better than other quinolones.(CONCLUSIONS) The antibacterial activity of pazufloxacin in vitro against the bacteria isolated from patients with(respiratory) and urinary tract infection is comparatively strong,especially in the urinary system.Pazufloxacin has an excellent broad-(spectrum) and strong antibacterial activity.However,the antibacterial activity against Gram-positive cocci is(expected) to promote.
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AIM To observe the effect of artesunate on content of progesterone, estrogen and decidua of pregnant rats and study the efficacy and mechanism of artesunate for termination of early pregnancy. METHODS Serum content of progesterone, estrogen and TNF-α were measured with RIA. The effects of artesunate on the ovary, decidua and fetus of pregnant rats were studied using histochemistry techniques. Decidual cells were estimated using cell culture. RESULTS Artesunate 40 mg*kg-1 sc on day 6-10 of gestation significantly decreased the concentration of serum progesterone in early pregnant rats; decidual cells and fetus of treated groups were found to be degenerated at d 11. Artesunate was shown to directly damage the decidual cells. Cultured human decidual cells were exposed to artesunate for 48 h, the LC50 was found to be 25±3 mL*L-1. CONCLUSION The damage of artesunate on decidua and placenta may be the mechanisms of its contragestational action.
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Aim To observe the inhibitory effect of dihydroartemisinin combined with COX-2 inhibitor on S180 sarcoma and their possible antitumor mechanisms.Methods The ICR mice model of the subcutaneous transplanting tumor was established by S180 sarcoma to investigate the treatment effect of dihydroartemisinin and COX-2 inhibitor.Expressions of VEGF,COX-2 and CD31 in S180 sarcoma were detected and the amount of leukocyte was also observed.Results Dihydroartemisinin combined with COX-2 inhibitor could potently inhibit tumor growth and inflammation.The maximal antitumor rate reached 55.38%.The results of immunohistochemistry showed that COX-2 and VEGF protein expressions were weakened by dihydroartemisinin and COX-2 inhibitor,versus the control groups.Further,RT-PCR analysis showed that the expression of VEGF mRNA was also effectively decreased.Finally,a significant down-regulation effect of COX-2 and VEGF protein expression was observed.Conclusions Dihydroartemisinin combined with COX-2 inhibitor can significantly inhibit S180 tumor.The antitumor mechanism of these two drugs might be closely related to the effect of COX-2 and VEGF expression suppression.